In the dynamic landscape of pharmaceutical formulation, delving deeper into the role of OSD excipients reveals a strategic customization that transcends the basics. Excipients such as Magnesium Stearate, Sodium Stearyl Fumarate, Stearic Acid, Calcium Stearate, and Polyethylene Glycol emerge as key players in sophisticated formulations, going beyond conventional applications. Customizing the surface area and particle size of these excipients takes center stage, playing a pivotal role in elevating formulation science to new heights. Take lubricants, for instance; their significance extends beyond mere flow enhancement during tablet compression. The tailored adjustment of surface area directly impacts their efficiency in minimizing friction between granules, ensuring uniform tablet weight, and mitigating issues like capping and sticking. This strategic customization becomes even more paramount in sustained release formulations. Here, the ability to precisely control particle size and surface area empowers formulators to craft a nuanced release profile for the active pharmaceutical ingredient (API). Through the adjustment of particle sizes and increased surface area, dissolution rates are optimized, fostering a sustained and controlled release over an extended period. This proves particularly valuable in addressing the demands of chronic conditions, where maintaining consistent drug levels is crucial for therapeutic efficacy. Moreover, in the realm of controlled release formulations, excipients emerge as architects of drug release kinetics. The fine-tuning made possible by customizing the surface area ensures a controlled and predictable release profile. Consider Polyethylene Glycol, with its adaptable molecular weight, offering formulators precision in controlling API diffusion and ultimately enhancing bioavailability and therapeutic outcomes. In conclusion, the strategic customization of surface area and particle size of OSD excipients propels formulation science beyond its foundational principles. This nuanced approach empowers pharmaceutical scientists to address challenges related to flowability, compression, and drug release kinetics, paving the way for the development of high-quality oral solid dosage forms with unparalleled therapeutic performance.